abstract：:The cytokine network of tumour microenvironment (TME) plays an important role in cancer growth and progression. The current work aims to provide a new strategy for cancer therapy based on the targeted regulation of cytokines in the TME. Here, heparin-coupled polyvinyl alcohol (PVA-H) microspheres have been developed a...

authors： Wang L,Chen J,Chai Y,Han W,Shen J,Li N,Lu J,Du Y,Liu Z,Yu Y,Dong J,Ou L

更新日期：2021-12-01 00:00:00

abstract：:Standardization is crucial when culturing cells including human embryonic stem cells (hESCs) which are valuable for therapy development and disease modeling. Inherent issues regarding reproducibility of protocols are problematic as they hinder translation to good manufacturing practice (GMP), thus reducing clinical ef...

authors： Kusena JWT,Shariatzadeh M,Thomas RJ,Wilson SL

更新日期：2021-12-01 00:00:00

abstract：:Transitional cell carcinoma (TCC) is the most common malignant tumor of the canine urinary tract. In this case study, a dog with metastatic urethral TCC was treated with sorafenib. The tumor expression levels of receptor tyrosine kinase genes, including VEGFR-1, VEGFR-2, PDGFR-α, PDGFR-β, ALK, EGFR, ErbB2, and B-RAF, ...

authors： Kim JH,Ahn DH,Moon JS,Han HJ,Bae K,Yoon KA

更新日期：2021-12-01 00:00:00

abstract：INTRODUCTION:Many types of research have been performed to improve the diagnosis, therapy, and prognosis of oropharyngeal carcinomas (OP-SCCs). Since they arise in lymphoid-rich areas and intense lymphocytic infiltration has been related to a better prognosis, a TREM-1 putative function in tumour progression and surviv...

authors： Azzimonti B,Raimondo L,Squarzanti DF,Rosso T,Zanetta P,Aluffi Valletti P,Chiusa L,Masini L,Pecorari G,Airoldi M,Krengli M,Giovarelli M,Valente G

更新日期：2021-12-01 00:00:00

abstract：:Influenza D virus (IDV), with bovines as a primary host, circulates widely in cattle populations across North America and Eurasia. Here we report the identification of a novel IDV group with broad antigenicity in U.S. bovine herds, which is genetically different from previously known lineages of IDV. ...

authors： Huang C,Yu J,Hause BM,Park JY,Sreenivasan C,Uprety T,Sheng Z,Wang D,Li F

更新日期：2021-12-01 00:00:00

abstract：:Minocycline hydrochloride (MINO) has been one of the most frequently used antibiotics in the treatment of periodontitis due to its antibacterial activity and osteogenesis effects; however, high levels of MINO administered during the treatment halt the formation of new bone. Therefore, the purpose of the present study ...

authors： Zhang T,Qiu Y,Song J,Zhou P,Liao H,Cheng Y,Wu X

更新日期：2021-12-01 00:00:00

abstract：:Introduction: Teen pregnancy remains a major social and public health issue in developing countries. Each additional child compromises the development of both the mother and children. Scarce studies have been performed in Latin America.Purpose: This study explores and analyzes individual and family factors associated ...

authors： Luttges C,Leal I,Huepe G,González D,González E,Molina T

更新日期：2021-12-01 00:00:00

abstract：:The serum intact parathyroid hormone (iPTH) is associated with the prognosis of hemodialysis (HD) patients, however, its optimal range for reducing mortality remains inconsistent. We designed a prospective cohort study of 346 incident HD patients to assess the association between different serum iPTH level and mortali...

authors： Zhou X,Guo Y,Luo Y

更新日期：2021-12-01 00:00:00

abstract：:Atrial fibrillation globally affects roughly 33.5 million people, making it the most common heart rhythm disorder. It is a crucial arrhythmia, as it is linked with a variety of negative outcomes such as strokes, heart failure and cardiovascular mortality. Atrial fibrillation can reduce quality of life because of the p...

authors： Alrumayh A,Alobaida M

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Targeted public health response to obesity in Nigeria is relatively low due to limited epidemiologic understanding. We aimed to estimate nationwide and sub-national prevalence of overweight and obesity in the adult Nigerian population. METHODS:MEDLINE, EMBASE, Global Health, and Africa Journals Online were ...

authors： Adeloye D,Ige-Elegbede JO,Ezejimofor M,Owolabi EO,Ezeigwe N,Omoyele C,Mpazanje RG,Dewan MT,Agogo E,Gadanya MA,Alemu W,Harhay MO,Auta A,Adebiyi AO

更新日期：2021-12-01 00:00:00

abstract：:Nano-drug delivery systems (NDDS) are functional drug-loaded nanocarriers widely applied in cancer therapy. Recently, layer-by-layer (LbL) assembled NDDS have been demonstrated as one of the most promising platforms in delivery of anticancer therapeutics. Here, a brief review of the LbL assembled NDDS for cancer treat...

authors： Zhang X,Liang T,Ma Q

更新日期：2021-12-01 00:00:00

abstract：:This study reports the synthesis of silver nanoparticles (AgNPs) from silver nitrate by leaf extract of a medicinal plant Ziziphus nummularia. The leaf extract acts as a reducing and stabilizing agent for the formation of nanoparticles. The green synthesized AgNPs were characterized by ultraviolet-visible (UV-vis) spe...

authors： Padalia H,Chanda S

更新日期：2021-12-01 00:00:00

abstract：CONTEXT:Polygonatum sibiricum polysaccharide (PSP), derived from Polygonatum sibiricum Delar. ex Redoute (Liliaceae), is known to be able to delay the ageing process. However, the specific mechanisms underlying these effects are not clear. OBJECTIVE:To investigate the mechanisms underlying the effects of PSP treatment...

authors： Zhang Z,Yang B,Huang J,Li W,Yi P,Yi M,Peng W

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVE:This study aimed to assess the diagnostic accuracy of serum LDH to pleural ADA ratio (cancer ratio, CR)for malignant pleural effusion (MPE) through an original study and meta-analysis. METHODS:We retrospectively collected data from 145 patients with MPE and 117 cases of benign pleural effusions (BPE). The di...

authors： Zhang Y,Li X,Liu J,Hu X,Wan C,Zhang R,Shen Y

更新日期：2021-12-01 00:00:00

abstract：:Axis formed by integrin β3 (ITGβ3)-Ras homolog gene family, member A (RhoA), and Yes-associated protein (YAP) plays an important role in atherosclerosis. In addition, ITGβ3 overexpression was noted in high-glucose (HG) exposure podocytes. However, the ITGβ3-RhoA-YAP axis on HG-induced podocyte injury remains unclear. ...

authors： Li Z,Lian Z,Ma J,Zhang L,Lian X,Liu S,Xie J,Feng Z,Lin T,Zhang H,Liang X

更新日期：2021-12-01 00:00:00

abstract：:Lupeol liposomes, modified with Gal-PEG-DSPE, were developed following a thin-film dispersion method. Then, the morphology, physicochemical properties, and in vitro release properties of those liposomes were investigated. The scanning electron microscopic images showed that most of the liposomes were spherical particl...

authors： Zhang J,Hu X,Zheng G,Yao H,Liang H

更新日期：2021-12-01 00:00:00

abstract：:Monitoring the humoral protective immune response and its durability after SARS-CoV-2 infections is essential for risk assessment of reinfections, the improvement of diagnostic methods and the evaluation of vaccine trials. We have analyzed neutralizing antibodies and IgG responses specific to different antigens, inclu...

authors： Rockstroh A,Wolf J,Fertey J,Kalbitz S,Schroth S,Lübbert C,Ulbert S,Borte S

更新日期：2021-12-01 00:00:00

abstract：:Preadipocyte proliferation is a critical and precisely orchestrated procedure in adipogenesis, which is highly regulated by microRNAs (miRNAs). A previous study identified that the expression of miR-33a is different in intramuscular fat (IMF) tissues from steers and bulls. In the present study, miR-33a was overexpress...

authors： Zhang W,Wang L,Raza SHA,Wang X,Wang G,Liang C,Cheng G,Li B,Zan L

更新日期：2021-12-01 00:00:00

abstract：:Our previous studies have implicated CaV3.2 isoform of T-type Ca2+ channels (T-channels) in the development of postsurgical pain. We have also previously established that different T-channel antagonists can alleviate in vivo postsurgical pain. Here we investigated the analgesic potential of another T-channel blocker a...

authors： Joksimovic SL,Lamborn N,Jevtovic-Todorovic V,Todorovic SM

更新日期：2021-12-01 00:00:00

abstract：:Moraxella catarrhalis is a bacterial pathogen that causes respiratory tract infections in humans. The increasing prevalence of antibiotic-resistant M. catarrhalis strains has created a demand for alternative treatment options. We therefore tested 23 insect antimicrobial peptides (AMPs) for their activity against M. ca...

authors： Bertrams W,Lindhauer NS,Rieke MC,Paas A,Hoffmann K,Greene B,Visekruna A,Vilcinskas A,Seidel K,Schmeck B

更新日期：2021-12-01 00:00:00

abstract：:In eukaryotes, calcium not only is an essential mineral nutrient but also serves as an intracellular second messenger that is necessary for many physiological processes. Previous studies showed that the protein phosphatase-calcineurin protects fungi from toxicity caused by the extracellular calcium; however, little is...

authors： Zhang C,Ren Y,Gu H,Gao L,Zhang Y,Lu L

更新日期：2021-12-01 00:00:00

abstract：:The world at large is facing a new threat with the emergence of the Coronavirus Disease 2019 (COVID-19) pandemic. Though imperceptible by the naked eye, the medical, sociological and economical implications caused by this newly discovered virus have been and will continue to be a great impediment to our lives. This he...

authors： Chia WY,Kok H,Chew KW,Low SS,Show PL

更新日期：2021-12-01 00:00:00

abstract：:Learning Health Systems (LHSs) seek continuous improvement through the translation and integration of internally and externally generated knowledge across stakeholders within and external to the organization, yet current approaches are primarily described from the healthcare delivery perspective, leaving teaching and ...

authors： McDonald PL,Van Der Wees P,Weaver GC,Harwood K,Phillips JR,Corcoran M

更新日期：2021-12-01 00:00:00

abstract：:A high prevalence of multidrug-resistant (MDR) pathogens has been reported in adult and pediatric populations of Pakistan. However, data describing the effect of MDR microbes on the gut microbiota is scarce. We designed a cross-sectional pediatric study to investigate the effect of MDR microbes' infection on the gut m...

authors： Afridi OK,Ali J,Chang JH

更新日期：2021-12-01 00:00:00

abstract：:Clostridium difficile (C. difficile) is a kind of obligate anaerobic gram-positive Bacillus related with intestinal diseases and antibiotic treatment. In present study, the C. difficile genome was studied employing met genomic technology. Genome sequencing identified C. difficile LCL126 has total size of 4,301,949 bp ...

authors： Wang J,Yang C,Zhang C,Mao X,Lizhe A

更新日期：2021-12-01 00:00:00

abstract：:The Angiotensin II/transforming growth factor-β1 (AngII/TGF-β1) signal axis is an important regulatory pathway for atrial fibrosis, which can contribute to atrial fibrillation (AF). Fused in sarcoma (FUS) was recently found to regulate cardiac diseases. This study aimed to investigate whether FUS could regulate AngII ...

authors： Wang G,Wu H,Liang P,He X,Liu D

更新日期：2021-12-01 00:00:00

abstract：:Traditional healers are commonly utilised throughout sub-Saharan Africa instead of - and in concert with - biomedical facilities. Traditional healers are trusted providers and prominent community members and could be important partners in improving engagement with HIV services in endemic contexts. Our study sought to ...

authors： Sundararajan R,Langa PV,Morshed T,Manuel S

更新日期：2021-12-01 00:00:00

abstract：:Severe Helicobacter pylori-linked gastric disorders are especially prevalent in the East Asia region. The ability of H. pylori to cause different clinical outcomes is thought to be associated with unique sets of its genetic features. However, only few genetic features have been definitively linked to specific gastroin...

authors： Yang F,Zhang J,Wang S,Sun Z,Zhou J,Li F,Liu Y,Ding L,Liu Y,Chi W,Liu T,He Y,Xiang P,Bao Z,Olszewski MA,Zhao H,Zhang Y

更新日期：2021-12-01 00:00:00

abstract：:Differentiated thyroid carcinoma (DTC) is one of the most common malignant tumors. Increasing evidence indicates that centromere protein K(CENPK) may play a key role in promoting carcinogenesis. The expression, biological functions, and clinical significance of CENPK in DTC are still unclear. The CENPK expression in t...

authors： Li Q,Liang J,Zhang S,An N,Xu L,Ye C

更新日期：2021-12-01 00:00:00

abstract：:In recent years, mental practice (MP) using laterally inverted video of a subject's non-paralyzed upper limb to improve the vividness of presented motor imagery (MI) has been shown to be effective for improving the function of a paralyzed upper limb. However, no studies have yet assessed the activity of cortical regio...

authors： Fujiwara K,Shibata M,Awano Y,Shibayama K,Iso N,Matsuo M,Nakashima A,Moriuchi T,Mitsunaga W,Higashi T

更新日期：2021-12-01 00:00:00

abstract：:Dysfunctional autophagy often occurs during the development of neurodegenerative diseases, such as Parkinson's disease, Huntington's disease, and Alzheimer's disease. The purinergic P2X4 receptor is an ATP-gated ion channel that is widely expressed in the microglia, astrocytes, and neurons of the central and periphera...

authors： Zhang X,Wang J,Gao JZ,Zhang XN,Dou KX,Shi WD,Xie AM

更新日期：2021-12-01 00:00:00

abstract：:Excess added sugar intake contributes to tooth decay risk in Alaska Native communities. The goal of this exploratory study was to determine if there is seasonal variation in total added sugar intake or in the leading sources of added sugars in a Yup'ik population. Data were collected in spring and winter from 2008-201...

authors： Hill C,Nash SH,Bersamin A,Hopkins SE,Boyer BB,O'Brien DM,Chi DL

更新日期：2021-12-01 00:00:00

abstract：AIM:Inconsistent investigations of the risk factors for all-cause mortality in patients undergoing peritoneal dialysis (PD) were reported. The present meta-analysis aimed to assess the impact of some clinical characteristics on the risk of mortality in PD patients. Methods: PubMed and Embase were systematically searche...

authors： Zhang J,Lu X,Li H,Wang S

更新日期：2021-12-01 00:00:00

abstract：:SARS-CoV-2 is a novel coronavirus that was isolated and identified for the first time in Wuhan, China in 2019. Nowadays, it is a worldwide danger and the WHO named it a pandemic. In this investigation, a functionalization post-synthesis method was used to assess the ability of an adapted SBA-15 surface as a sorbent to...

authors： Alazzawi HF,Salih IK,Albayati TM

更新日期：2021-12-01 00:00:00

abstract：:Shiga toxin-producing Escherichia coli, a foodborne bacterial pathogen, has been linked to a broad spectrum of clinical outcomes ranging from asymptomatic carriage to fatal hemolytic uremic syndrome (HUS). Here, we collected clinical data and STEC strains from HUS patients from 1994 through 2018, whole-genome sequenci...

authors： Hua Y,Chromek M,Frykman A,Jernberg C,Georgieva V,Hansson S,Zhang J,Marits AK,Wan C,Matussek A,Bai X

更新日期：2021-12-01 00:00:00

abstract：:Over the past decade, minimally invasive sacroiliac joint (SIJ) fusion has become an effective treatment for patients suffering from low back pain (LBP) originating from the SIJ. Perioperative C-arm fluoroscopy-assisted surgical navigation during SIJ fusion remains challenging due to the lack of 3D spatial information...

authors： Schippers B,Hekman E,van Helden S,Boomsma M,van Osch J,Nijveldt R

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:The role of indoxyl sulfate (IS), an important protein-bound uremic toxin, in arterial stiffness (AS) in patients with chronic kidney disease (CKD) is unclear. MATERIALS AND METHODS:We investigated the association between serum IS levels and AS in a cross-sectional study of 155 patients with CKD. Patients i...

authors： Wang SC,Lai YH,Liu CH,Wang CH,Hsu BG,Tsai JP

更新日期：2021-12-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most common primary liver malignancy in adults, ranking the second leading cause of cancer-related death. To date, the underlying mechanisms of HCC pathogenesis are still unclear. Recently, more and more studies have reported that long noncoding RNAs (lncRNAs) are involved in the ...

authors： Song W,Wenhui Z,Ruiqiang Y,Hu X,Shi T,Wang M,Zhang H

更新日期：2021-12-01 00:00:00

abstract：:N-methyl-D-aspartate receptors (NMDARs) are excitatory ionotropic glutamate receptors expressed throughout the CNS, including in the spinal dorsal horn. The GluN2 subtypes of NMDAR subunit, which include GluN2A, GluN2B, and GluN2D in the dorsal horn, confer NMDARs with structural and functional variability, enabling h...

authors： Temi S,Rudyk C,Armstrong J,Landrigan JA,Dedek C,Salmaso N,Hildebrand ME

更新日期：2021-12-01 00:00:00

abstract：:Human-induced pluripotent stem cell (hiPSC) and stem cell (hSC) derived cardiomyocytes (CM) are gaining popularity as in vitro model for cardiology and pharmacology studies. A remaining flaw of these cells, as shown by single-cell electrophysiological characterization, is a more depolarized resting membrane potential ...

authors： Van de Sande DV,Kopljar I,Maaike A,Teisman A,Gallacher DJ,Bart L,Snyders DJ,Leybaert L,Lu HR,Labro AJ

更新日期：2021-12-01 00:00:00